L.E.D. Therapy
Light emitting diodes bring relief to young cancer patients; NASA technology used
for plant growth now in clinical trials

     A device using specialized light emitting diodes, based on NASA technology for plant
growth in space, is continuing to show promise as a treatment to aid healing of bone
marrow transplant patients. Use of the LED apparatus has advanced to the second phase
of clinical trials in U.S. and foreign hospitals. Results from the first round of tests were
highly encouraging, prompting researchers to expand the trials as they seek approval for
the treatment as a standard of care for oral mucositis.
     A nurse holds a strange-looking device, moving it slowly toward a young patient’s
face. The note-card-sized device is covered with glowing red lights, but as it comes closer,
the youngster shows no fear. He's hopeful this painless procedure using an array of lights
will help ease or prevent some of the pain and discomfort associated with cancer treatment.
     The youngster is participating in the second phase of human clinical trials for this light
healing device. The first round of tests by Medical College of Wisconsin researchers at
Children’s Hospital of Wisconsin in Milwaukee, was so encouraging that doctors have
expanded the trials to several U.S. and foreign hospitals.
     “We've already seen how using LEDs can improve a bone marrow transplant patient's
quality of life," said Dr. Harry Whelan, professor of neurology, pediatrics and hyperbaric
medicine at the Medical College of Wisconsin in Milwaukee. "These trials will hopefully
help us take the next steps to provide this as a standard of care for this ailment.”
     The light is produced by light emitting diodes, or LEDs. They are used in hundreds of
applications, from electronic clock displays to jumbo TV screens.
     These LEDs provide light for plants grown on the Space Station as part of commercial
experiments sponsored by industry under the Space Product Development Program at
NASA’s Marshall Space Flight Center in Huntsville, Ala. Researchers discovered that the
diodes also had many promising medical applications, prompting this research to be funded
by a NASA Small Business Innovation Research contract through the Technology Transfer
Department at the Marshall Center.
     Biologists have found that cells exposed to near-infrared light — that is, energy just
outside the visible range — from LEDs grow 150 to 200 percent faster than those cells not
stimulated by such light. The light arrays increase energy inside cells that speed up the
healing process.
     In the first stage of the study, use of the LEDs resulted in significant relief to pediatric
bone marrow transplant patients suffering the ravages of oral mucositis, a common side
effect of chemotherapy and radiation treatments according to Dr. David Margolis,
associate professor of pediatrics at the Medical College. He works with Dr. Whelan on the
study at Children’s Hospital of Wisconsin, a major teaching affiliate of the Medical College.
     Many times young bone marrow transplant recipients contract this condition that
produces ulcerations in the mouth and throat, severe pain, and in some cases, inflammation
of the entire gastro-intestinal tract. Swelling and bleeding occur, and chewing and
swallowing become difficult, if not impossible — affecting a child's overall health because
of reduced drinking and eating.
     "Our first study was very encouraging, and using the LED device greatly reduced or
prevented the mucositis problem, which is so painful and devastating to these children,"
said Whelan. "But we still need to learn more. We're conducting further clinical trials with
larger groups and expanded control groups, as required by the U.S. Food and Drug
Administration, before the device can be approved and available for widespread use."
     The clinical trials are expected to take approximately three years with a total of 80
patients. Participants currently include the Medical College of Wisconsin in Milwaukee;
Roswell Park Cancer Institute in Buffalo, N.Y. and Instituto de Oncologia Pediatrica, in
Sao Paulo, Brazil. Rush-Presbyterian-St. Luke's Medical Center in Chicago; University of
Illinois Medical Center in Chicago; Hospital Sirio Libanes in Sao Paulo Brazil; and
Hadassah University Medical Center in Jerusalem, Israel have also asked to join the multi-
center study.
     In the first clinical study, the team examined each patient's mouth, tongue and throat.
They asked the patient to rate the current level of pain before treatment. Each patient
received one minute of LED therapy starting the day of the bone marrow transplant and a
one-minute treatment each day thereafter for a two-week period.
     The treatment device was a 3-by-5-inch portable, flat array of light-emitting diodes. It
was held on the outside of a patient's left cheek for just over a minute each day. The
process was repeated over the patient's right cheek, but with foil placed between the LED
array and the patient to provide a sham treatment for comparison. There wasn't any
treatment of the throat area, which provided the control for the first study.
     The researchers compared the percentage of patients with ulcerative oral mucositis to
historical epidemiological controls. Just 53 percent of the treated patients in the bone
marrow transplant group developed mucositis, considerably less than the usual rate of 70-
90 percent. Patients also reported pain reduction in their mouths when compared to
untreated pain seven days following bone marrow transplant.
     Quantum Devices of Barneveld, Wis., makes the wound-healing LED device. The
company specializes in the manufacture of silicon photodiodes — semiconductor devices
used for light detection — and light emitting diodes for commercial, industrial and medical
applications.
     For supporting materials for this news release — such as photographs, fact sheets,
video and audio files and more — please visit the NASA Marshall Center Newsroom
Web site at   http://www.msfc.nasa.gov/news

********************************************************************
Light Therapy For Skin
Look Better, Look Younger, Naturally

That’s a fact, light therapy for skin is an effective skin care treatment. Professionals such as
dermatologists and spas are using the technology as an anti-aging or acne solution. Studies
have shown that up to 90% of people see improvements of their skin condition, it became
inevitable that home use devices would be created from the professional technology and
equipment you can find at dermatologists or skin care centers.

Actually, brands that manufacture professional light therapy products also manufactures the
personal LED light therapy devices (Omnilux, Baby Quasar, Evis…).

Born From NASA Research

The LED light therapy technology has been researched by NASA, not just for skin
problems, but also to fight cancer, for pain relief purpose and even to grow plants. Light
therapy is also used for affective disorders, sleep disorders, to boost energy, but this is not
the same kind of light. We would just want to warn you : because this technology has been
researched by NASA doesn’t mean your device is equiped with the exact same
technology.

So yes, light therapy devices are actually “based on a technology researched by NASA”
but when you see products advertised with some “NASA” words, this is just a bit of
marketing only. Of course, this is still LED light therapy, and light therapy devices you will
find on this website have all proven to be effective.

So what light therapy can do for your skin ?

As we said earlier, light therapy (for skin) is mainly used to treat aging and acne. It is very
common to see that red light therapy is associated with anti-aging and blue light therapy to
fight acne.

In the anti-aging process, what is important is the collagen production, and red light therapy
stimulates the collagen production. Collagen is responsible for the elasticity and firmness of
your skin, resulting in the reduction of fine lines and wrinkles. The collagen is also the
protein that repair damaged skin cells. You look younger and have a healthier skin.

The blue light therapy kills the Propionibacterium acnes bacteria. This bacteria is one of the
cause of acne, and is sensitive to light in a certain range (405 to 420 nm). The bacteria
absorbs the light and the light kills the bacteria. Acne vanishes as a result. Because red light
is more the “healing light”, it is also used for acne : it reduces the inflammation caused by
acne, reduces scarring and sebum and oil production. You look better, your skin is clear.

********************************************************************

All aspects of wrinkling, skin coarseness, pore size, irregular pigmentation showed
visible improvement with Photo Rejuvenation. — Dermatology Times

Photo Rejuvenation treatments...the results are the closet thing to a face lift that
I've been able to achieve since becoming an aesthetician. — Day Spa Magazine

The treatment is especially effective at improving the appearance of the face,
neck and chest, by reducing signs of aging, wrinkles and age spots. — Web M.D.
Health

A process called Photo Rejuvenation can smooth away wrinkles, erase age spots
and relieve the symptoms of Rosacea. — ABC‘s Good Morning America

********************************************************************

All information is for educational purposes only.  These statements have not been evaluated by the Food
and Drug Administration.  These products are not intended to diagnose, treat, cure or prevent any
disease.